Comparison of Necropsy Findings in Patients With Sarcoidosis Dying Suddenly from Cardiac Sarcoidosis Versus Dying Suddenly from Other Causes

The clinical diagnosis of cardiac sarcoidosis can be difficult and is largely dependent on newer imaging modalities. A retrospective search of sudden cardiac deaths was performed from a reference laboratory and statewide medical examiner system for a 12-year period. Planimetry was performed on gross...

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Bibliographic Details
Published in:The American journal of cardiology 2009-08, Vol.104 (4), p.571-577
Main Authors: Tavora, Fabio, MD, Cresswell, Nathaniel, MS, Li, Ling, MD, Ripple, Mary, MD, Solomon, Carol, MD, Burke, Allen, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Autopsy
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiomyopathies - mortality
Cardiomyopathies - pathology
Cardiovascular
Cardiovascular disease
Cause of Death
Comparative studies
Death & dying
Death, Sudden - etiology
Death, Sudden - pathology
Female
Heart Ventricles - pathology
Humans
Male
Medical diagnosis
Medical imaging
Medical sciences
Middle Aged
Myocardium - pathology
Necrosis
Retrospective Studies
Sarcoidosis - mortality
Sarcoidosis - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Ventricular Septum - pathology
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Summary:The clinical diagnosis of cardiac sarcoidosis can be difficult and is largely dependent on newer imaging modalities. A retrospective search of sudden cardiac deaths was performed from a reference laboratory and statewide medical examiner system for a 12-year period. Planimetry was performed on gross photographs of transverse short-axis sections, and the phase of the lesion and the portion of myocardium extent was estimated histologically. Lesions were classified histologically as early (primarily lymphocytic), intermediate (primarily granulomatous), and late (primarily scar). A total of 41 cases were found, including 25 in which the death was ascribed to sarcoidosis of the heart (group 1) and 16 in which sudden death was due to other findings (group 2). No significant differences were found in age or activity at death, although gross scars and epicardial nodules were more frequent in group 1 (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2009.03.068