Reliable manual segmentation of the frontal, parietal, temporal, and occipital lobes on magnetic resonance images of healthy subjects

Background: It is a challenge to reliably measure the lobar volumes from magnetic resonance imaging (MRI) data. Objective: Description of a landmark-based method for volumetric segmentation of the brain into the four cerebral lobes from MR images. Method: The segmentation method relies on a combinat...

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Bibliographic Details
Published in:Brain research. Brain research protocols 2005-04, Vol.14 (3), p.135-145
Main Authors: Bokde, Arun L.W., Teipel, Stefan J., Schwarz, Robert, Leinsinger, Gerda, Buerger, Katharina, Moeller, Tobias, Möller, Hans-Juergen, Hampel, Harald
Format: Article
Language:English
Subjects:
Aged
Anatomical landmark
Brain lobes
Brain Mapping - methods
Cerebral Cortex - anatomy & histology
Cerebrum
Female
Frontal Lobe - anatomy & histology
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Male
Middle Aged
Occipital Lobe - anatomy & histology
Parietal Lobe - anatomy & histology
Regional segmentation
Reproducibility of Results
Temporal Lobe - anatomy & histology
Volumetric segmentation
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Summary:Background: It is a challenge to reliably measure the lobar volumes from magnetic resonance imaging (MRI) data. Objective: Description of a landmark-based method for volumetric segmentation of the brain into the four cerebral lobes from MR images. Method: The segmentation method relies on a combination of anatomical landmarks and geometrical definitions. The first step, described previously, is a segmentation of the four lobes on the surface of the brain. The internal borders between the lobes are defined on the axial slices of the brain. The intra- and inter- rater reliability was determined from the MRI scans of a group of 10 healthy control subjects measured by 2 independent raters. Results: The intra-rater relative error (and intra-class correlation coefficient) of the lobar volume measures ranged from 0.81% to 3.85% (from 0.97 to 0.99). The inter-rater relative error (and intra-class correlation coefficient) ranged from 0.55% to 3.09% (from 0.94 to 0.99). Conclusion: This technique has been shown to have high intra- and inter-rater reliability. The current method provides a method to obtain volumetric estimates of the 4 cerebral lobes.
ISSN:1385-299X
DOI:10.1016/j.brainresprot.2004.10.001