Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating...

Full description

Saved in:
Bibliographic Details
Published in:Cell metabolism 2009-08, Vol.10 (2), p.99-109
Main Authors: Cheung, Grace W.C., Kokorovic, Andrea, Lam, Carol K.L., Chari, Madhu, Lam, Tony K.T.
Format: Article
Language:English
Subjects:
Animals
Cholecystokinin - metabolism
Devazepide - pharmacology
Dietary Fats - pharmacology
Duodenum - innervation
Duodenum - metabolism
Glucose - metabolism
Insulin - metabolism
Insulin Resistance
Male
Nerve Net - physiology
Rats
Rats, Sprague-Dawley
Receptor, Cholecystokinin A - antagonists & inhibitors
Receptor, Cholecystokinin A - deficiency
Receptor, Cholecystokinin A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating insulin levels. Furthermore, we show that duodenal CCK-8 requires the activation of the gut CCK-A receptor and a gut-brain-liver neuronal axis to lower glucose production. Finally, duodenal CCK-8 fails to lower glucose production in the early onset of high-fat diet-induced insulin resistance. These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2009.07.005