Stereocomplex Block Copolymer Micelles:  Core−Shell Nanostructures with Enhanced Stability

Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene glycol)-block-poly(l-lactide) and poly(ethylene glycol)-block-poly(d-lactide) in water. These micelles possessed partially crystallized cores and mean hydrodynamic diame...

Full description

Saved in:
Bibliographic Details
Published in:Nano letters 2005-02, Vol.5 (2), p.315-319
Main Authors: Kang, Ning, Perron, Marie-Ève, Prud'homme, Robert E, Zhang, Yubao, Gaucher, Geneviève, Leroux, Jean-Christophe
Format: Article
Language:English
Subjects:
Colloids - analysis
Colloids - chemistry
Crystallization - methods
Kinetics
Lactates - analysis
Lactates - chemistry
Materials Testing
Micelles
Molecular Conformation
Nanostructures - analysis
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
Polyethylene Glycols - analysis
Polyethylene Glycols - chemistry
Solutions
Stereoisomerism
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene glycol)-block-poly(l-lactide) and poly(ethylene glycol)-block-poly(d-lactide) in water. These micelles possessed partially crystallized cores and mean hydrodynamic diameters ranging from 31 to 56 nm, depending on the lactide content. They exhibited kinetic stability and redispersion properties superior to micelles prepared with isotactic or racemic polymers alone. This study demonstrates the advantages of stereocomplex formation in the design of stabilized water-soluble nanoparticles.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl048037v