19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum

A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes.

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Bibliographic Details
Published in:Natural product research 2009, Vol.23 (12), p.1108-1111
Main Authors: Traoré-Coulibaly, Maminata, Ziegler, Hanne L, Olsen, Carl Erik, Hassanata, Millogo-kone, Pierre, Guissou I, Nacoulma, Odile G, Guiguemdé, T Rober, Christensen, S Brøgger
Format: Article
Language:English
Subjects:
Animals
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Erythrocytes - drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plasmodium falciparum - drug effects
Rubiaceae - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Description
Summary:A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes.
ISSN:1478-6427
DOI:10.1080/14786410802401481