Impact of Time to Reperfusion After Acute Myocardial Infarction on Myocardial Damage Assessed by Left Ventricular Longitudinal Strain

• Published in: The American journal of cardiology 2009-08, Vol.104 (4), p.480-485
• Main Authors: Bertini, Matteo, MD, Mollema, Sjoerd A., MD, Delgado, Victoria, MD, Antoni, M. Louisa, MD, Ng, Arnold C.T., MBBS, Holman, Eduard R., MD, PhD, Boriani, Giuseppe, MD, PhD, Schalij, Martin J., MD, PhD, Bax, Jeroen J., MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cohort Studies; Coronary heart disease; Echocardiography, Doppler, Color; Female; Heart; Heart attacks; Heart surgery; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocarditis. Cardiomyopathies; Risk Factors; Stress, Mechanical; Stroke Volume - physiology; Studies; Time Factors; Troponin T - blood; Ventricular Function, Left - physiology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2009.04.010

The relation between cardiac troponin T (cTnT) and regional strain in patients with acute myocardial infarction (AMI) was investigated. Furthermore, the effect of symptoms-to-balloon time on impairment in regional strain after AMI was evaluated. A total of 157 consecutive patients with AMI who underwent primary percutaneous coronary intervention were included. Two-dimensional echocardiography soon after percutaneous coronary intervention was performed. Speckle-tracking analysis was applied to assess left ventricular global and regional longitudinal peak systolic strain (LPSS). Infarcted area was defined based on the culprit vessel. Mean left ventricular ejection fraction was 47 ± 7%. Global LPSS was −14.4 ± 3.2%. The infarcted area LPSS was significantly decreased compared with global LPSS (−11.3 ± 4.5%, p