Primary Squamous Cell Carcinoma of the Breast: Achieving Long-Term Control With Cisplatin-Based Chemotherapy

Abstract Pure primary squamous cell carcinoma (SCC) of the breast is rare and difficult to treat. Published series suggest a poor response to conventional breast chemotherapy. A 66-year-old woman with locally advanced SCC of the breast received combined-modality treatment with high-dose radiation th...

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Bibliographic Details
Published in:Clinical breast cancer 2009-08, Vol.9 (3), p.187-188
Main Authors: Bhatt, Lubna, Fernando, Indrajit
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - administration & dosage
Breast Neoplasms - drug therapy
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - surgery
Cisplatin - administration & dosage
Combined Modality Therapy
Combined-modality treatment
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Humans
Ifosfamide
Ifosfamide - administration & dosage
Mastectomy
Mitomycin - administration & dosage
Mitomycin-C
Obstetrics and Gynecology
Platinum-based chemotherapy
Radiation therapy
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Summary:Abstract Pure primary squamous cell carcinoma (SCC) of the breast is rare and difficult to treat. Published series suggest a poor response to conventional breast chemotherapy. A 66-year-old woman with locally advanced SCC of the breast received combined-modality treatment with high-dose radiation therapy (59 Gy in 22 fractions); mastectomy; and chemotherapy with cisplatin 50 mg/m2 , mitomycin-C 6 mg/m2 , and ifosfamide 3 g/m2 given in 21-day cycles. She remained disease free for 10 years from presentation and died from an unrelated cause. We would suggest that this case lends support to the use of high-dose radiation therapy and platinum-based chemotherapy in the management of this difficult condition.
ISSN:1526-8209
1938-0666
DOI:10.3816/CBC.2009.n.031