Vulnerability to depression: what is the role of stress genes in gene x environment interaction?

Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar &...

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Bibliographic Details
Published in:Psychological medicine 2009-09, Vol.39 (9), p.1407-1411
Main Authors: El Hage, W, Powell, J F, Surguladze, S A
Format: Article
Language:English
Subjects:
Alleles
Amygdala - physiopathology
Arousal - genetics
Arousal - physiology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Epistasis, Genetic - genetics
Gene Expression Regulation - genetics
Genetic Predisposition to Disease - genetics
Genetics
Gyrus Cinguli - physiopathology
Humans
Hypothalamo-Hypophyseal System - physiopathology
Life Change Events
Mental depression
Phenotype
Pituitary-Adrenal System - physiopathology
Polymorphism
Polymorphism, Genetic - genetics
Receptors, Glucocorticoid - genetics
Receptors, Mineralocorticoid - genetics
Risk factors
Serotonin Plasma Membrane Transport Proteins - genetics
Social Environment
Stress
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Summary:Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307-313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene x environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291709005236