Normal N400 in mood disorders

Individuals diagnosed with major depression have been characterized as having a variety of cognitive problems based on a number of behavioral and psychophysiological measures, but it is not clear whether there is a consistent language processing abnormality in depression. Three studies sought to det...

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Bibliographic Details
Published in:Biological psychology 2006, Vol.71 (1), p.74-79
Main Authors: Deldin, Patricia, Keller, Jennifer, Casas, Brooks R., Best, Jennifer, Gergen, John, Miller, Gregory A.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Behavioral psychophysiology
Biological and medical sciences
Brain - physiology
Depression
Depressive Disorder, Major - psychology
Dysthymia
Dysthymic Disorder - psychology
Electroencephalography
Electromyography
Electrophysiology
ERP
Evoked Potentials - physiology
Eye Movements
Female
Fundamental and applied biological sciences. Psychology
Humans
Language
Major depression
Male
Medical sciences
Mood disorders
N400
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Semantic processing
Semantics
Speech Perception - physiology
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Summary:Individuals diagnosed with major depression have been characterized as having a variety of cognitive problems based on a number of behavioral and psychophysiological measures, but it is not clear whether there is a consistent language processing abnormality in depression. Three studies sought to determine whether diverse mood disordered samples show abnormal semantic processing, as indexed by a failure to show increased N400 event-related brain potential amplitudes to passively viewed incongruent, relative to congruent sentence endings. Individuals with major depression ( N = 50) or dysthymia ( N = 14) had N400 amplitudes similar to those of controls ( N = 41) in this sentence processing paradigm. These results are consistent with a small behavioral literature suggesting intact semantic processing in depression and further indicate that abnormal controlled processing in some tasks does not simply reflect a generalized deficit.
ISSN:0301-0511
1873-6246
DOI:10.1016/j.biopsycho.2005.02.005