Local umbilical cord blood renin-angiotensin system

Local bone marrow (BM) renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin II type 1a (AT1a) receptors are present on the CD34(+) hematopoietic stem cells (HSC). Angiotensin II stimulates the proliferation and differentiation of...

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Bibliographic Details
Published in:Annals of hematology 2005-05, Vol.84 (5), p.277-281
Main Authors: Goker, Hakan, Haznedaroglu, Ibrahim C, Beyazit, Yavuz, Aksu, Salih, Tuncer, Serdar, Misirlioglu, Muge, Bayramoglu, Fatma, Kekilli, Murat, Büyükasik, Yahya, Sayinalp, Nilgun, Ozcebe, Osman, Dundar, Semra, Mollamahmutoglu, Leyla
Format: Article
Language:English
Subjects:
Angiotensin II - biosynthesis
Angiotensinogen - biosynthesis
Autocrine Communication - physiology
Bone marrow
Cell Proliferation
Female
Fetal Blood - cytology
Fetal Blood - metabolism
Hematopoiesis - physiology
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Paracrine Communication - physiology
Peptidyl-Dipeptidase A - biosynthesis
Pregnancy
Renin - biosynthesis
Renin-Angiotensin System - physiology
Stem cells
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Summary:Local bone marrow (BM) renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin II type 1a (AT1a) receptors are present on the CD34(+) hematopoietic stem cells (HSC). Angiotensin II stimulates the proliferation and differentiation of the HSC populations through the activation of AT1 receptors on HSC. Umbilical cord blood (UCB) is a rich source of HSC. The existence of a complete local UCB RAS has not been previously investigated. In this study, local synthesis of the major RAS components, namely, angiotensin-converting enzyme (ACE), renin, and angiotensinogen, was identified by demonstrating their corresponding mRNAs using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in human UCB. Local RAS could regulate cellular growth in a variety of tissues including the BM. Major RAS peptides can exert significant effects on primitive pluripotential HSC populations. Further studies should focus on the interactions between possible autocrine, paracrine, endocrine, and intracrine actions of the local UCB RAS and growth, engraftment, differentiation, and plasticity functions of HSC of UCB origin.
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-004-0989-x