Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients

Eosinophilic esophagitis in adults is a recently described entity occurring in young males with dysphagia, in whom esophageal biopsies show eosinophilic infiltration. This study defines the clinical and histological features of patients with eosinophilic esophagitis, distinguishing it from gastroeso...

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Bibliographic Details
Published in:Modern pathology 2006-01, Vol.19 (1), p.90-96
Main Authors: Parfitt, Jeremy R, Gregor, James C, Suskin, Neville G, Jawa, Hani A, Driman, David K
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Deglutition Disorders - complications
Diagnosis, Differential
eosinophil
Eosinophilia - pathology
eosinophilic
esophagitis
Esophagitis - complications
Esophagitis - pathology
Esophagus - pathology
Gastroesophageal Reflux - pathology
Humans
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
original-article
Pathology
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Summary:Eosinophilic esophagitis in adults is a recently described entity occurring in young males with dysphagia, in whom esophageal biopsies show eosinophilic infiltration. This study defines the clinical and histological features of patients with eosinophilic esophagitis, distinguishing it from gastroesophageal reflux disease. Esophageal biopsies from patients with dysphagia or esophagitis were reviewed blindly, and assessed for: epithelial eosinophil counts, presence of eosinophilic microabscesses, edema, basal zone hyperplasia, lamina propria papillae elongation, eosinophils and fibrosis. Clinical and endoscopic findings were obtained. Eosinophilic esophagitis was diagnosed with epithelial eosinophils ≥15 in ≥2 high-power fields (hpfs) or ≥25 in any hpf. Analysis was performed with Mann–Whitney, χ2 and ANOVA tests. Of 157 cases, 41 had eosinophilic esophagitis. Male gender (81%) and age ≤45 (54%) were commoner in patients with eosinophilic esophagitis (P=0.001, 0.010, respectively). Dysphagia was more common in eosinophilic esophagitis patients (63%, P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.3800498