Changes in bone mineral density, body composition and biochemical markers of bone turnover during weight gain in adolescents with severe anorexia nervosa : a 1-year prospective study

• Published in: Osteoporosis international 2006, Vol.17 (1), p.77-84
• Main Authors: COMPSTON, J. E, MCCONACHIE, C, STOTT, C, HANNON, R. A, KAPTOGE, S, DEBIRAM, I, LOVE, S, JAFFA, A
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anorexia; Anorexia Nervosa - complications; Anorexia Nervosa - physiopathology; Anorexia Nervosa - therapy; Anthropometry; Automation; Biological and medical sciences; Biomarkers - metabolism; Body Composition; Body mass index; Bone Density; Bone Remodeling; Creatinine; Diseases of the osteoarticular system; Female; Femur Neck - physiopathology; Fundamental and applied biological sciences. Psychology; Growth; Hip Joint - physiopathology; Humans; Investigative techniques, diagnostic techniques (general aspects); Lumbar Vertebrae - physiopathology; Medical sciences; Medicine; Mineralization; Osteoarticular system. Muscles; Osteoporosis; Osteoporosis - etiology; Osteoporosis - physiopathology; Osteoporosis. Osteomalacia. Paget disease; Phosphatase; Prospective Studies; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Skeleton and joints; Teenagers; Vertebrates: osteoarticular system, musculoskeletal system; Weight Gain
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-005-1904-6

Osteoporosis is a serious complication of anorexia nervosa and in affected adolescents may result in a permanent deficit in bone mass. The pathophysiology of this bone disease has not been clearly defined. In this prospective study of 26 young women with anorexia nervosa aged 13-20 years (mean 16.5) we have measured changes in bone mineral density, total body composition and biochemical indices of bone turnover over 1 year. Over this period there was a mean weight gain of 10 kg and significant height gain with baseline and final values for body mass index of 14.2+/-1.7 and 17.6+/-2.3 kg/m2 (P