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True carcinosarcoma of the esophagus

Most esophageal carcinosarcomas are diagnosed as so‐called carcinosarcoma, in which individual elements may be derived from a single common ancestor cell, and there have been a few reports describing true carcinosarcoma originating from two individual stem cells. We describe a case of esophageal car...

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Bibliographic Details
Published in:Diseases of the esophagus 2006-02, Vol.19 (1), p.48-52
Main Authors: Iwaya, T., Maesawa, C., Uesugi, N., Kimura, T., Ogasawara, S., Ikeda, K., Kimura, Y., Mitomo, S., Ishida, K., Sato, N., Saito, K., Masuda, T.
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Language:English
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Summary:Most esophageal carcinosarcomas are diagnosed as so‐called carcinosarcoma, in which individual elements may be derived from a single common ancestor cell, and there have been a few reports describing true carcinosarcoma originating from two individual stem cells. We describe a case of esophageal carcinosarcoma exhibiting neoplastic osteoid formation. Immunoreactivity for vimentin and p53 was limited to only the sarcomatous component and was absent in the carcinomatous component. Furthermore, a point mutation in exon 7 of the p53 gene was observed only in the sarcomatous component. Both sarcoma and carcinoma cells distinctively metastasized to different lymph nodes. These observations led us to diagnose the esophageal tumor as a true carcinosarcoma.
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2006.00538.x