Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis

Abstract In the present study, we investigated the B-cell translocation gene 1 ( BTG1 ) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients...

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Bibliographic Details
Published in:Journal of neuroimmunology 2009-08, Vol.213 (1), p.142-147
Main Authors: Camiña-Tato, M, Morcillo-Suárez, C, Navarro, A, Fernández, M, Horga, A, Montalban, X, Comabella, M
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
B-cell translocation gene 1
DNA Mutational Analysis
Female
Gene Frequency - genetics
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Genetic Testing
Genotype
Haplotypes - genetics
Humans
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis - genetics
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Neoplasm Proteins - genetics
Neurology
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Polymorphisms
Risk Factors
Secondary Prevention
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Summary:Abstract In the present study, we investigated the B-cell translocation gene 1 ( BTG1 ) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients and 548 controls. For SNP rs731652, significant associations with relapse-onset MS were found at the allele and genotype levels when compared with controls. We identified a risk haplotype associated with relapse-onset MS. These findings support the hypothesis that BTG1 polymorphisms may influence genetic predisposition for MS, especially in relapse-onset MS patients.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2009.05.010