Molecular insights into the phylogeny of canine parvovirus 2 (CPV-2) with emphasis on Korean isolates: a Bayesian approach

A Bayesian approach was utilized to further investigate the molecular phylogeny of canine parvovirus 2 (CPV-2) with emphasis on Korean isolates, and the complete VP2 gene sequences for 23 Korean isolates in 2007 and two vaccine strains were determined. Of the 44 Korean CPVs, 40 were identified as CP...

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Bibliographic Details
Published in:Archives of virology 2009, Vol.154 (8), p.1353-1360
Main Authors: Yoon, Sook Hee, Jeong, Wooseog, Kim, Hyun-Jeong, An, Dong-Jun
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Amino acids
Animals
Bayes Theorem
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brief Report
Canine parvovirus
Cloning
Dog Diseases - virology
Dogs
Fundamental and applied biological sciences. Psychology
Infectious Diseases
Korea
Medical Microbiology
Microbiology
Miscellaneous
Molecular Sequence Data
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Parvovirus, Canine - classification
Parvovirus, Canine - genetics
Phylogenetics
Phylogeny
Vaccines
Viral Structural Proteins - genetics
Virology
Viruses
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Summary:A Bayesian approach was utilized to further investigate the molecular phylogeny of canine parvovirus 2 (CPV-2) with emphasis on Korean isolates, and the complete VP2 gene sequences for 23 Korean isolates in 2007 and two vaccine strains were determined. Of the 44 Korean CPVs, 40 were identified as CPV-2a, three as CPV-2b, and the remaining one as a CPV-2a variant having a Gly300Asp mutation. Compared with CPV-2a, our findings also showed the presence of six additional amino acid substitutions (Thr440Ala, Ile418Thr, Pro435Ser, Asp413Asn, Thr322Ser, and Tyr324Ile) within the VP2 gene of the Korean isolates. In the phylogenetic tree, the overall Korean CPVs did not emerge as an independent clade within the global CPVs, nor did they show a close relationship to the CPVs from any other country. Our VP2 sequence data also revealed no geographic influence on the spread of CPVs worldwide. dN/dS analysis showed that purifying selection is acting on the VP2 gene of Korean CPVs.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-009-0444-3