No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor ( CHRM2 ). In an attempt to replicate this finding we typed mar...

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Bibliographic Details
Published in:Behavior genetics 2009-09, Vol.39 (5), p.513-523
Main Authors: Lind, Penelope A., Luciano, Michelle, Horan, Michael A., Marioni, Riccardo E., Wright, Margaret J., Bates, Timothy C., Rabbitt, Patrick, Harris, Sarah E., Davidson, Yvonne, Deary, Ian J., Gibbons, Linda, Pickles, Andrew, Ollier, William, Pendleton, Neil, Price, Jackie F., Payton, Antony, Martin, Nicholas G.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alcoholism
Alzheimer's disease
Australia
Behavioral Science and Psychology
Clinical Psychology
Cognition & reasoning
Cognition - physiology
Cognitive abilities
Cognitive ability
Cohort Studies
England
Epidemiology
Family Health
Female
Genes
Genetic factors
Genetic Markers
Genetic Variation
Genetics
Health Psychology
Humans
Independent sample
Intelligence - genetics
Male
Memory
Middle Aged
Original Research
Polymorphism, Single Nucleotide
Psychology
Public Health
Receptor, Muscarinic M2 - genetics
Scotland
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Summary:Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor ( CHRM2 ). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years ( N  = 2,091) and the other English comprising non-demented elderly participants ( N  = 758)—and a family-based Australian adolescent sample ( N  = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-009-9274-z