Getting the message across: cytoplasmic ribonucleoprotein complexes

mRNA–ribonucleoprotein (mRNP) complexes mediate post-transcriptional control mechanisms in the cell nucleus and cytoplasm. Transcriptional control is paramount to gene expression but is followed by regulated nuclear pre-mRNA maturation and quality control processes that culminate in the export of a...

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Bibliographic Details
Published in:Trends in plant science 2009-08, Vol.14 (8), p.443-453
Main Authors: Bailey-Serres, J., Sorenson, Reed, Juntawong, Piyada
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Transport
Cytoplasm - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Protein Binding
Protein Processing, Post-Translational
Ribonucleoproteins - metabolism
RNA, Messenger - metabolism
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Summary:mRNA–ribonucleoprotein (mRNP) complexes mediate post-transcriptional control mechanisms in the cell nucleus and cytoplasm. Transcriptional control is paramount to gene expression but is followed by regulated nuclear pre-mRNA maturation and quality control processes that culminate in the export of a functional transcript to the cytoplasm. Once in the cytosol, mRNPs determine the activity of individual mRNAs through regulation of localization, translation, sequestration and turnover. Here, we review how quantitative assessment of mRNAs in distinct cytoplasmic mRNPs, such as polyribosomes (polysomes), has provided new perspectives on post-transcriptional regulation from the global to gene-specific level. In addition, we explore recent genetic and biochemical studies of cytoplasmic mRNPs that have begun to expose RNA-binding proteins in an integrated network that fine-tunes gene expression.
ISSN:1360-1385
1878-4372
DOI:10.1016/j.tplants.2009.05.004