The Ped-APS Registry: the antiphospholipid syndrome in childhood

In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international...

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Bibliographic Details
Published in:Lupus 2009-09, Vol.18 (10), p.894-899
Main Authors: Avčin, T, Cimaz, R, Rozman, B
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - epidemiology
Child
Collaboration
Hospitals
Humans
Immunology
Laboratories
Lupus
Pediatrics
Registries
Rheumatology
Thrombosis
Thrombosis - etiology
Working groups
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Summary:In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international registry of paediatric patients with APS (the Ped-APS Registry) was initiated in 2004 to foster and conduct multicentre, controlled studies with large number of paediatric APS patients. The Ped-APS Registry is organised as a collaborative project of the European Forum on Antiphospholipid Antibodies and Juvenile Systemic Lupus Erythematosus Working Group of the Paediatric Rheumatology European Society. Currently, it documents a standardised clinical, laboratory and therapeutic data of 133 children with antiphospholipid antibodies (aPL)-related thrombosis from 14 countries. The priority projects for future research of the Ped-APS Registry include prospective enrolment of new patients with aPL-related thrombosis, assessment of differences between the paediatric and adult APS, evaluation of proinflammatory genotype as a risk factor for APS manifestations in childhood and evaluation of patients with isolated nonthrombotic aPL-related manifestations.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203309106917