Reduced vitamin D in acute stroke

Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. We compared the...

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Bibliographic Details
Published in:Stroke (1970) 2006, Vol.37 (1), p.243-245
Main Authors: POOLE, Kenneth E. S, LOVERIDGE, Nigel, BARKER, Peter J, HALSALL, David J, ROSE, Collette, REEVE, Jonathan, WARBURTON, Elizabeth A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Case-Control Studies
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Male
Medical sciences
Middle Aged
Models, Statistical
Nervous system (semeiology, syndromes)
Neurology
Pharmacology. Drug treatments
Risk Factors
Seasons
Stroke - blood
Stroke Rehabilitation
Time Factors
Vascular diseases and vascular malformations of the nervous system
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
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Summary:Stroke leads to a reduction in bone mineral density, altered calcium homeostasis, and an increase in hip fractures. Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke. We compared the serum 25-dihydroxyvitamin D levels of 44 patients admitted to an acute stroke unit with first-ever stroke with results obtained by measuring 96 healthy ambulant elderly subjects every 2 months for 1 year. Statistical Z scores of serum vitamin D were then calculated after seasonal adjustment for the month of sampling. The mean Z score of vitamin D in acute stroke was -1.4 SD units (95% CI, -1.7, -1.1), with 77% of patients falling in the insufficient range. Reduced vitamin D was identified in the majority of patients with acute stroke throughout the year and may have preceded stroke. Vitamin D is a potential risk marker for stroke, and the role of vitamin D repletion in enhancing musculoskeletal health after stroke needs to be explored.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000195184.24297.c1