Adrenocortical carcinoma extending into the inferior vena cava: Presentation of a 15-patient series and review of the literature

• Published in: Surgery 2006, Vol.139 (1), p.15-27
• Main Authors: Chiche, Laurent, Dousset, Bertrand, Kieffer, Edouard, Chapuis, Yves
• Format: Article
• Language: English
• Subjects: Adolescent; Adrenal Cortex Neoplasms - diagnosis; Adrenal Cortex Neoplasms - mortality; Adrenal Cortex Neoplasms - pathology; Adrenal Cortex Neoplasms - surgery; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adrenocortical Carcinoma - diagnosis; Adrenocortical Carcinoma - mortality; Adrenocortical Carcinoma - secondary; Adrenocortical Carcinoma - surgery; Adult; Aged; Aged, 80 and over; Angiography; Biological and medical sciences; Endocrinopathies; Female; Follow-Up Studies; General aspects; Humans; Magnetic Resonance Imaging; Male; Malignant tumors; Medical sciences; Middle Aged; Neoplasm Invasiveness - diagnostic imaging; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local; Prognosis; Reoperation; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome; Vena Cava, Inferior - diagnostic imaging; Vena Cava, Inferior - pathology
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/j.surg.2005.05.014

Involvement of the inferior vena cava (IVC) is a controversial risk factor for surgical treatment of adrenocortical carcinoma (ACC). This study aims to assess the outcome of an aggressive surgical policy for ACC extending into the IVC and discuss treatment strategies based on a review of the literature. Over a 25-year period, 15 patients were treated for ACC extending into the IVC. The upper limit of the extension was the infrahepatic IVC in 2 patients, retrohepatic IVC in 6, and suprahepatic IVC in 7, including 4 with extension into the right atrium. Seven patients presented with concurrent metastases. The operative technique was thrombectomy (n = 13), partial resection with direct closure (n = 1), and total resection with replacement of the IVC (n = 1). Venous control was achieved by caval clamping alone (n = 4), hepatic vascular exclusion (n = 5), and the use of normothermic cardiopulmonary bypass or hypothermic circulatory arrest (n = 6). Two patients died postoperatively. Ten patients died of metastatic complications at 4 to 31 months. Median survival time was 8 months. Three patients were still alive after 24, 25, and 45 months of follow-up, one of whom was reoperated at 17 months for a local recurrence. No evidence of recurrent intravenous involvement was found during follow-up in any patient in whom complete resection was achieved. Our findings suggest that surgical treatment can be effective for management of ACC with extension into the IVC. Long-term prognosis is poor owing to delay in diagnosis, frequent associated metastatic disease and lack of effective adjuvant treatment.