Antibody formation against β-tubulin class III in response to brain trauma

Brain trauma typically leads to neuronal damage and loss. Assuming a transient autoimmune response to debris of the damaged neurones, we have monitored serum titres of IgG and IgM antibodies to β-tubulin class III (βTcIII), which is almost exclusively found in neuronal cytoskeletons. In 15 out of 18...

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Bibliographic Details
Published in:Brain research bulletin 2006-01, Vol.68 (4), p.213-216
Main Authors: Škoda, D., Kranda, K., Bojar, M., Glosová, L., Bäurle, J., Kenney, J., Romportl, D., Pelichovská, M., Cvachovec, K.
Format: Article
Language:English
Subjects:
Antibody Formation
Autoantibodies
Brain - immunology
Brain Injuries - blood
Brain Injuries - immunology
Brain injury
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Neuronal loss
Neurons - immunology
Time Factors
Tubulin - immunology
β-Tubulin class III
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Summary:Brain trauma typically leads to neuronal damage and loss. Assuming a transient autoimmune response to debris of the damaged neurones, we have monitored serum titres of IgG and IgM antibodies to β-tubulin class III (βTcIII), which is almost exclusively found in neuronal cytoskeletons. In 15 out of 18 patients, the peak of the IgG or IgM antibody titre appeared in the serum within 3 weeks of a brain trauma.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2005.05.032