Lisuride treatment of restless legs syndrome: first studies with monotherapy in de novo patients and in combination with levodopa in advanced disease

In two 4-week polysomnography pilot studies with 10 patients each, we investigated the efficacy of oral lisuride as monotherapy in de novo RLS patients as well as in combination with levodopa in advanced RLS. Daily doses at study end were 0.3 mg lisuride, plus 150 mg levodopa in the combination stud...

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Bibliographic Details
Published in:Journal of Neural Transmission 2006-01, Vol.113 (1), p.87-92
Main Authors: Benes, H, Deissler, A, Rodenbeck, A, Engfer, A, Kohnen, R
Format: Article
Language:English
Subjects:
Adult
Aged
Drug Therapy, Combination
Female
Humans
Levodopa - administration & dosage
Lisuride - administration & dosage
Male
Middle Aged
Pilot Projects
Polysomnography - drug effects
Restless Legs Syndrome - drug therapy
Restless Legs Syndrome - physiopathology
Single-Blind Method
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Summary:In two 4-week polysomnography pilot studies with 10 patients each, we investigated the efficacy of oral lisuride as monotherapy in de novo RLS patients as well as in combination with levodopa in advanced RLS. Daily doses at study end were 0.3 mg lisuride, plus 150 mg levodopa in the combination study. Marked improvements occurred in both studies in different PLM indexes and in the CGI. Levodopa dose could be decreased by 27%. Lisuride might be an efficacious treatment for RLS in general, and in combination with levodopa in advanced stage.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-005-0386-1