Increased insulin resistance and β cell activity in patients with Crohn's disease

Background: Pancreatitis and exocrine pancreatitic insufficiency have been described as extraintestinal manifestations of inflammatory bowel disease. In this study, we investigated whether the endocrine pancreatic function is also disturbed in patients with inflammatory bowel disease. Methods: Seven...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2006-01, Vol.12 (1), p.53-56
Main Authors: Bregenzer, Nicole, Hartmann, Alexander, Strauch, Ulrike, Schölmerich, Jürgen, Andus, Tilo, Bollheimer, L Cornelius
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
C-Peptide - blood
Crohn Disease - metabolism
Crohn's disease
endocrine pancreas function
Female
Glucose Tolerance Test
Homeostasis - physiology
Humans
Insulin - blood
Insulin - metabolism
Insulin Resistance
Insulin Secretion
Insulin-Secreting Cells - metabolism
Male
Middle Aged
oral glucose tolerance test
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Summary:Background: Pancreatitis and exocrine pancreatitic insufficiency have been described as extraintestinal manifestations of inflammatory bowel disease. In this study, we investigated whether the endocrine pancreatic function is also disturbed in patients with inflammatory bowel disease. Methods: Seventeen patients with Crohn's disease and 13 healthy volunteers participated in the study. We analyzed the plasma insulin response in a 75‐g oral glucose tolerance test. Glucose and insulin levels were determined at time 0 (fasting levels) and 30, 60, 90, 120, 180, 240, and 300 min after glucose uptake. Insulin resistance and β cell function (BCF) were analyzed by calculating respective indices. Results: Fasting and oral glucose‐tolerance test glucose levels appeared to be similar in patients with Crohn's disease and in the controls. Impaired fasting glucose, impaired glucose tolerance, and/or overt diabetes mellitus were not observed in the volunteers. Insulin as well as the index for BCF were significantly increased in patients with Crohn's disease. In addition, insulin resistance was shown to be significantly elevated in Crohn's disease. Conclusions: Patients with Crohn's disease reveal an increased insulin secretion caused by an enhanced BCF, which may be induced by an up‐regulated enteropancreatic axis. This hypersecretion may override the insulin resistance given by the chronic inflammatory state.
ISSN:1078-0998
1536-4844
DOI:10.1097/01.MIB.0000195975.97673.f5