Molecular neurodevelopment: An in vivo 31P-1H MRSI study

Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children a...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2009-09, Vol.15 (5), p.671-683
Main Authors: GOLDSTEIN, GERALD, PANCHALINGAM, KANAGASABAI, MCCLURE, RICHARD J., STANLEY, JEFFREY A., CALHOUN, VINCE D., PEARLSON, GODFREY D., PETTEGREW, JAY W.
Format: Article
Language:English
Subjects:
Achievement tests
Adolescent
Adolescent development
Age Factors
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Autism
Brain
Brain - diagnostic imaging
Brain - growth & development
Brain - physiology
Brain Mapping
Child
Child development
Cognition
Cognition - physiology
Cognitive ability
Cognitive development
Consent
Executive function
Female
Humans
Magnetic Resonance Spectroscopy
Male
Mental disorders
Neuropsychological Tests
Pediatrics
Phosphocreatine
Phosphocreatine - metabolism
Phospholipid metabolism
Phosphorus Radioisotopes - metabolism
Protons
Psychologists
Radionuclide Imaging
Spectrum Analysis
Statistics as Topic
Synapses
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Description
Summary:Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617709990233