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Molecular neurodevelopment: An in vivo 31P-1H MRSI study
Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children a...
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| Published in: | Journal of the International Neuropsychological Society 2009-09, Vol.15 (5), p.671-683 |
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| Main Authors: | , , , , , , |
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| container_end_page | 683 |
| container_issue | 5 |
| container_start_page | 671 |
| container_title | Journal of the International Neuropsychological Society |
| container_volume | 15 |
| creator | GOLDSTEIN, GERALD PANCHALINGAM, KANAGASABAI MCCLURE, RICHARD J. STANLEY, JEFFREY A. CALHOUN, VINCE D. PEARLSON, GODFREY D. PETTEGREW, JAY W. |
| description | Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders. |
| doi_str_mv | 10.1017/S1355617709990233 |
| format | article |
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Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. 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metabolism</subject><subject>Phospholipid metabolism</subject><subject>Phosphorus Radioisotopes - metabolism</subject><subject>Protons</subject><subject>Psychologists</subject><subject>Radionuclide Imaging</subject><subject>Spectrum Analysis</subject><subject>Statistics as Topic</subject><subject>Synapses</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqF0LtOwzAUBmALgWgpPAALihjYAj6-xmyo0AtqBbRFjJETu1JKLiVOKvr2GLUwsDDZ0v_p-PdB6BzwNWCQN3OgnAuQEiulMKH0AHWBCRVKIeDQ330cfucddOLcCmOggPEx6oASknFMuyiaVrlN21zXQWnbujJ2Y_NqXdiyuQ3uyiArg022qQIKzyGMgulsPg5c05rtKTpa6tzZs_3ZQ6-Dh0V_FE6ehuP-3STMwD8QJinhkHKdMKJTyYFrwIkwPBUqYRIzargUigEQmhiVLjG3ZIl9OUOFIYmgPXS1m7uuq4_WuiYuMpfaPNelrVoXC8kVRAL_CwkQzHCkPLz8A1dVW5f-E95EkWCRlB5d7FGbFNbE6zordL2NfzbnQbgDmWvs52-u63dfiUoei-FL_Mjk_fRtNogX9AuAIHtJ</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>GOLDSTEIN, GERALD</creator><creator>PANCHALINGAM, KANAGASABAI</creator><creator>MCCLURE, RICHARD J.</creator><creator>STANLEY, JEFFREY A.</creator><creator>CALHOUN, VINCE D.</creator><creator>PEARLSON, GODFREY D.</creator><creator>PETTEGREW, JAY W.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Molecular neurodevelopment: An in vivo 31P-1H MRSI study</title><author>GOLDSTEIN, GERALD ; PANCHALINGAM, KANAGASABAI ; MCCLURE, RICHARD J. ; STANLEY, JEFFREY A. ; CALHOUN, VINCE D. ; PEARLSON, GODFREY D. ; PETTEGREW, JAY W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1503-bc251c5ab42ac7515a10b6d5c69b47043d576941123bd9cf05e2f0745d36d2b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Achievement tests</topic><topic>Adolescent</topic><topic>Adolescent development</topic><topic>Age Factors</topic><topic>Aspartic Acid - 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| identifier | ISSN: 1355-6177 |
| ispartof | Journal of the International Neuropsychological Society, 2009-09, Vol.15 (5), p.671-683 |
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| language | eng |
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| source | Cambridge University Press |
| subjects | Achievement tests Adolescent Adolescent development Age Factors Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Autism Brain Brain - diagnostic imaging Brain - growth & development Brain - physiology Brain Mapping Child Child development Cognition Cognition - physiology Cognitive ability Cognitive development Consent Executive function Female Humans Magnetic Resonance Spectroscopy Male Mental disorders Neuropsychological Tests Pediatrics Phosphocreatine Phosphocreatine - metabolism Phospholipid metabolism Phosphorus Radioisotopes - metabolism Protons Psychologists Radionuclide Imaging Spectrum Analysis Statistics as Topic Synapses |
| title | Molecular neurodevelopment: An in vivo 31P-1H MRSI study |
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