EAE: An immunologist's magic eye

EAE comes in many shapes and colors. Individual variants of EAE present a baffling complexity of different aspects and traits, clinical, immunological, and structural. But, embedded in this seemingly chaotic image, the educated eye will discern patterns that retrace fundamental features of immune re...

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Bibliographic Details
Published in:European journal of immunology 2009-08, Vol.39 (8), p.2031-2035
Main Authors: Krishnamoorthy, Gurumoorthy, Wekerle, Hartmut
Format: Article
Language:English
Subjects:
Animal models
Animals
Autoimmunity
Autoimmunity - immunology
B-Lymphocytes - immunology
Cell Lineage - immunology
Disease Models, Animal
EAE
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - pathology
Humans
Self Tolerance - immunology
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:EAE comes in many shapes and colors. Individual variants of EAE present a baffling complexity of different aspects and traits, clinical, immunological, and structural. But, embedded in this seemingly chaotic image, the educated eye will discern patterns that retrace fundamental features of immune response, in particular, autoimmunity and self-tolerance. EAE and its variants thus can be likened to an autostereogram, i.e. they are an immunologist's magic eye.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200939568