Memory B cells: Effectors of long‐lived immune responses

Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent encounter with Ag relative to the initial exposure. In this review, we examine recent developments in the phenotypic characterisation of memory B cells,...

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Bibliographic Details
Published in:European journal of immunology 2009-08, Vol.39 (8), p.2065-2075
Main Authors: Tangye, Stuart G., Tarlinton, David M.
Format: Article
Language:English
Subjects:
Animals
B cells
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell differentiation
Cell Differentiation - genetics
Cell Differentiation - immunology
Gene Expression
Germinal Center - cytology
Germinal Center - immunology
Germinal Center - metabolism
Humans
Immunologic Memory - genetics
Immunologic Memory - immunology
Immunophenotyping
Memory cells
Models, Biological
Mutation
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Summary:Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent encounter with Ag relative to the initial exposure. In this review, we examine recent developments in the phenotypic characterisation of memory B cells, with an emphasis on the definition and functional properties of memory B‐cell subsets in humans. Gene expression differences are also considered in light of the unique functional and survival properties of memory B cells, and mutations that alter memory formation and function are also examined. Finally, we consider recent advances in the understanding of germinal center B‐cell differentiation through analysis of transcription factor networks operating in these B cells.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200939531