Tuning inflammation in tuberculosis: the role of decoy receptors

Decoy receptors are “silent scavengers” of CC chemokines and cytokines, which play a key role in damping inflammation and tissue damage. In this review we discuss on recent findings demonstrating that these receptors set the balance between antimicrobial resistance, immune activation and inflammator...

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Bibliographic Details
Published in:Microbes and infection 2009-09, Vol.11 (10), p.821-827
Main Authors: Di Liberto, Diana, Caccamo, Nadia, Meraviglia, Serena, Guggino, Giuliana, La Manna, Marco P., Sireci, Guido, Salerno, Alfredo, Dieli, Francesco
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Biological and medical sciences
Chemokines
Cytokines
Decoy receptors
Fundamental and applied biological sciences. Psychology
Humans
Immunopathology
Inflammation
Inflammation - immunology
Inflammation - pathology
Mice
Microbiology
Miscellaneous
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Receptors, Cytokine - immunology
TIR8/SIGIRR
Tuberculosis - immunology
Tuberculosis - pathology
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Summary:Decoy receptors are “silent scavengers” of CC chemokines and cytokines, which play a key role in damping inflammation and tissue damage. In this review we discuss on recent findings demonstrating that these receptors set the balance between antimicrobial resistance, immune activation and inflammatory response in Mycobacterium tuberculosis infection.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2009.05.004