SUPERFICIALLY ELEVATED‐TYPE SERRATED HYPERPLASTIC LESION OF THE STOMACH WITH MINUTE ADENOCARCINOMA

We report a case of gastric serrated hyperplastic lesion with minute adenocarcinoma. A 65‐year‐old Japanese man underwent endoscopic submucosal dissection to the superficially elevated‐type (0‐IIa) lesion located at the lesser curvature of the gastric angle. Histological observation revealed hyperpl...

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Bibliographic Details
Published in:Digestive endoscopy 2009-04, Vol.21 (2), p.101-105
Main Authors: Hasuo, Tadateru, Semba, Shuho, Satake, Shinya, Shirasaka, Daisuke, Aoyama, Nobuo, Yokozaki, Hiroshi
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - therapy
Aged
Dissection
Gastroscopy
Humans
Hyperplasia
Male
p53 mutation
serrated hyperplastic lesion
stomach
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
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Summary:We report a case of gastric serrated hyperplastic lesion with minute adenocarcinoma. A 65‐year‐old Japanese man underwent endoscopic submucosal dissection to the superficially elevated‐type (0‐IIa) lesion located at the lesser curvature of the gastric angle. Histological observation revealed hyperplastic change of foveolar epithelium with serrated glandular structure as well as a minute tubular adenocarcinoma component. Immunohistochemically, the lesion demonstrated gastrointestinal, predominantly gastric, phenotype (MUC5AC++, MUC6+, MUC2+, CD10−). Positive p53 immunoreactivity was detected in the carcinoma component of the lesion with a point mutation (G877T; R209I) of the gene and microsatellite instability of the BAT‐RII locus; however, immunoreactivity of the mismatch repair gene product hMLH1 was well preserved in the cancer as well as in the hyperplastic lesion. The hyperplastic lesion with serrated glandular pattern would be a precancerous lesion of adenocarcinoma of the stomach.
ISSN:0915-5635
1443-1661
DOI:10.1111/j.1443-1661.2009.00831.x