Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease

Background and Aim:  Patients with non‐alcoholic fatty liver disease (NAFLD) have an increased risk of atherosclerosis and alanine aminotransferase (ALT) is associated with insulin resistance independently of metabolic factors. The aim of the present study was to investigate whether NAFLD patients w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2009-08, Vol.24 (8), p.1411-1416
Main Authors: Wang, Chia-Chi, Lin, Shinn-Kuang, Tseng, Yuan-Fu, Hsu, Ching-Sheng, Tseng, Tai-Chung, Lin, Hans Hsienhong, Wang, Li-Yu, Kao, Jia-Horng
Format: Article
Language:English
Subjects:
Adult
alanine aminotransferase
Alanine Transaminase - blood
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - enzymology
Carotid Artery Diseases - etiology
Carotid Artery, Common - diagnostic imaging
carotid ultrasonography
Case-Control Studies
Fatty Liver - complications
Fatty Liver - diagnostic imaging
Fatty Liver - enzymology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis C virus
Humans
intima-media thickness
Liver - enzymology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Logistic Models
Male
Medical sciences
Middle Aged
non-alcoholic fatty liver disease
Odds Ratio
Other diseases. Semiology
Predictive Value of Tests
Risk Assessment
Risk Factors
Ultrasonography
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aim:  Patients with non‐alcoholic fatty liver disease (NAFLD) have an increased risk of atherosclerosis and alanine aminotransferase (ALT) is associated with insulin resistance independently of metabolic factors. The aim of the present study was to investigate whether NAFLD patients with ALT elevation had a higher risk of carotid atherosclerosis. Methods:  A total of 190 individuals were enrolled from the health management center. Among them, 20 subjects were excluded due to the presence of hepatitis B surface antigen (HbsAg), anti‐hepatitis C virus (HCV) and cardiovascular disease. NAFLD was diagnosed by ultrasound examination. Carotid ultrasonography was used to measure maximal intima‐media thickness (IMT) of the common carotid artery (CCA) and IMT (mean) > 1.0 mm was defined as the presence of carotid atherosclerosis. Results:  NAFLD patients with ALT elevation had increased risk of carotid atherosclerosis than those with normal ALT by Fisher's exact test (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2009.05872.x