Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)

Studies in animals show that vitamin D deficiency is associated with impaired insulin sensitivity, and that insulin secretion can be increased by vitamin D supplementation. Epidemiological studies in man show associations between low vitamin levels and glucose intolerance. Pittas et al. systematical...

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Bibliographic Details
Published in:Age and ageing 2009-09, Vol.38 (5), p.606-609
Main Authors: Avenell, Alison, Cook, Jonathan A., MacLennan, Graeme S., McPherson, Gladys C.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Calcium
Calcium - administration & dosage
Cholecalciferol - administration & dosage
Clinical trials
Diabetes
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - prevention & control
Drug Therapy, Combination
Female
Fractures, Spontaneous - epidemiology
Fractures, Spontaneous - prevention & control
Glucose Intolerance - epidemiology
Glucose Intolerance - prevention & control
Humans
Insulin
Male
Metabolic Syndrome - epidemiology
Metabolic Syndrome - prevention & control
Older people
Osteoporosis - drug therapy
Osteoporosis - epidemiology
Placebos
Prevention
Risk Factors
Type 2 diabetes mellitus
Vitamin D
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - prevention & control
Vitamins
Vitamins - administration & dosage
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Summary:Studies in animals show that vitamin D deficiency is associated with impaired insulin sensitivity, and that insulin secretion can be increased by vitamin D supplementation. Epidemiological studies in man show associations between low vitamin levels and glucose intolerance. Pittas et al. systematically reviewed the intervention trial evidence for the role of vitamin D and/or calcium in the prevention of metabolic syndrome and type 2 diabetes mellitus. On the basis of evidence from small intervention trials or post hoc analyses of trials, they concluded that it was difficult to be definite whether or not vitamin D and/or calcium were important in the prevention of type 2 diabetes, and that effects might only be manifest in people who were particularly at risk of type 2 diabetes.
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/afp109