The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells

Two isoforms of cyclooxygenase (COX) are known, and to date most studies have implicated COX-2 in the development and progression of various human cancers. Increasing evidence suggests that COX-1 may also play a similar role. Indeed, we have recently observed that the dual COX-1/COX-2 inhibitor indo...

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Published in:International journal of molecular medicine 2006-02, Vol.17 (2), p.245-252
Main Authors: Lampiasi, Nadia, Foderà, Daniela, D'Alessandro, Natale, Cusimano, Antonella, Azzolina, Antonina, Tripodo, Claudio, Florena, Ada, Minervini, Marta, Notarbartolo, Monica, Montalto, Giuseppe, Cervello, Melchiorre
Format: Article
Language:English
Subjects:
Aged
Apoptosis - drug effects
Carcinoma, Hepatocellular - enzymology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Cell Proliferation - drug effects
Cyclooxygenase 1 - genetics
Cyclooxygenase 1 - metabolism
Cyclooxygenase 2 - genetics
Cyclooxygenase 2 - metabolism
Cyclooxygenase Inhibitors - pharmacology
Female
Gene Expression Regulation, Enzymologic - genetics
Gene Expression Regulation, Neoplastic - genetics
Humans
Immunohistochemistry
Male
Middle Aged
Pyrazoles - pharmacology
RNA, Messenger - genetics
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Summary:Two isoforms of cyclooxygenase (COX) are known, and to date most studies have implicated COX-2 in the development and progression of various human cancers. Increasing evidence suggests that COX-1 may also play a similar role. Indeed, we have recently observed that the dual COX-1/COX-2 inhibitor indomethacin induces apoptosis in human hepatocellular carcinoma (HCC) cell lines more effectively than the selective COX-2 inhibitors, possibly implicating COX-1 in HCC. In this study we investigated the expression of COX-1 in non-tumor and malignant human liver tissues, as well as the effects of the highly selective COX-1 inhibitor SC-560 on cell growth and apoptosis in human HCC cell lines. Expression of COX-1 was detected in nearly all the samples assayed, although with a high variability between non-tumoral (NT) and malignant tissues. The percentage of COX-1 positive cells was significantly higher in the NT tissues than in the tumors (p
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.17.2.245