Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome

Objective:  Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment‐naïve boys with TS using magnetic resonance imaging (MRI). Method:  Volumetric MRI was performed on 18 treatment‐naïve...

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Bibliographic Details
Published in:Acta psychiatrica Scandinavica 2006-01, Vol.113 (1), p.64-67
Main Authors: Lee, J.-S., Yoo, S.-S., Cho, S.-Y., Ock, S.-M., Lim, M.-K., Panych, L. P.
Format: Article
Language:English
Subjects:
Adolescent
Adult and adolescent clinical studies
Biological and medical sciences
Child
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Functional Laterality - physiology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Neurology
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
thalamus
Thalamus - abnormalities
Thalamus - physiopathology
Tourette syndrome
Tourette Syndrome - diagnosis
Tourette Syndrome - physiopathology
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Summary:Objective:  Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment‐naïve boys with TS using magnetic resonance imaging (MRI). Method:  Volumetric MRI was performed on 18 treatment‐naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. Results:  Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. Conclusion:  Our findings provide new evidence of abnormal thalamic volume in pediatric TS.
ISSN:0001-690X
1600-0447
DOI:10.1111/j.1600-0447.2005.00666.x