In vivo regeneration of small-diameter (2 mm) arteries using a polymer scaffold

The difficulty of obtaining significant long‐term patency and good wall mechanical strength in vivo has been a significant obstacle in achieving small‐diameter vascular prostheses. The aim of the present study was to develop a prosthetic graft that could perform as a small‐diameter vascular conduit....

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Bibliographic Details
Published in:The FASEB journal 2006-01, Vol.20 (1), p.103-105
Main Authors: Lepidi, Sandro, Abatangelo, Giovanni, Vindigni, Vincenzo, Deriu, Giovanni Paolo, Zavan, Barbara, Tonello, Carolin, Cortivo, Roberta
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Aorta, Abdominal - metabolism
Aorta, Abdominal - surgery
Arteries - growth & development
Arteries - transplantation
Biocompatible Materials
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Cell Adhesion
Endothelium, Vascular - metabolism
Hyaluronic Acid - chemistry
Male
Rats
Rats, Wistar
remodeling
surgery
Time Factors
tissue engineering
Tissue Engineering - instrumentation
Tissue Engineering - methods
Vascular Patency
vascular prosthesis
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Summary:The difficulty of obtaining significant long‐term patency and good wall mechanical strength in vivo has been a significant obstacle in achieving small‐diameter vascular prostheses. The aim of the present study was to develop a prosthetic graft that could perform as a small‐diameter vascular conduit. Tubular structures of hyaluronan (HYAFF‐11 tubules, 2 mm diameter, 1 cm length) were grafted in the abdominal aorta of 30 rats as temporary absorbable guides to promote regeneration of vascular structures. Performance was assessed by histology, immunohistochemistry, and ultra‐structural analysis. These experiments resulted in three novel findings: 1) complete endothelialization of the tube's luminal surface occurred; 2) sequential regeneration of vascular components led to complete vascular wall regeneration 15 days after surgery; and 3) the biomaterial used created the ideal environment for the delicate regeneration process during the critical initial phases, yet its biodegradability allowed for complete degradation of the construct four months after implantation, at which time, a new artery remained to connect the artery stumps. This study assesses the feasibility to create a completely biodegradable vascular regeneration guide in vivo, able to sequentially orchestrate vascular regeneration events needed for very small artery reconstruction.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.05-4802fje