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Complex regulation of CCR9 at multiple discrete stages of T cell development

We have conducted a comprehensive assessment of CCR9 expression and function at the important milestone stages of murine thymocyte development. We reveal an unusually complex regulatory pattern, in which CCR9 influences T cell development at several widely dispersed stages. We find that CCR9 is not...

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Bibliographic Details
Published in:European Journal of Immunology 2006-01, Vol.36 (1), p.73-81
Main Authors: Wurbel, Marc‐André, Malissen, Bernard, Campbell, James J.
Format: Article
Language:English
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Summary:We have conducted a comprehensive assessment of CCR9 expression and function at the important milestone stages of murine thymocyte development. We reveal an unusually complex regulatory pattern, in which CCR9 influences T cell development at several widely dispersed stages. We find that CCR9 is not expressed within the thymus until the double‐negative (DN)3 stage, although it appears to contribute to T cell precursor development prior to residence in the thymus. CCR9 expression is influenced by pre‐T cell receptor signals, and is dramatically up‐regulated in a population that appears to be transitional between the DN4 and double‐positive stages. In the periphery, functional CCR9 is expressed by all naive CD8 T cells, but not by naive CD4 T cells. To our knowledge, this latter finding is the first difference observed in homing receptor expression between naive lymphocyte populations. This suggests that naive CD8 T cells might have access to lymphoid microenvironments from which naive CD4 T cells are excluded.
ISSN:0014-2980
1521-4141
1365-2567
DOI:10.1002/eji.200535203