Association of polymorphisms in the chemokine receptor CX3CR1 gene with coronary artery disease

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2009-09, Vol.47 (3), p.224-227
• Main Authors: Matzhold, Eva M., Trummer, Olivia, Grünbacher, Gerda, Zulus, Barbara, Boehm, Bernhard O., März, Winfried, Renner, Wilfried
• Format: Article
• Language: English
• Subjects: Age; Alleles; C-reactive protein; Cardiovascular diseases; Chemokine receptors; Coronary artery disease; Coronary Artery Disease - genetics; Cross-Sectional Studies; CX3C Chemokine Receptor 1; CX3CR1 protein; Cytokines; Data processing; Diabetes mellitus; Dyslipidemia; Female; Gene polymorphism; Genetic Predisposition to Disease; Genetics; Haplotypes; Heart diseases; Humans; Hypertension; Linkage disequilibrium; Male; Middle Aged; Myocardial infarction; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide; Receptors, Chemokine - genetics; Risk factors; Smoking
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2009.06.010

Two chemokine receptor CX3CR1 gene variants, V249I and T280M, have been implicated in coronary artery diseases (CAD). Currently no consistent effect has been revealed and their role in cardiovascular disease is still conflicting. In the present study the association of CX3CR1 genotypes with CAD and myocardial infarction (MI) was investigated in the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort, including 3316 individuals in whom cardiovascular disease angiographically has been defined or ruled out. Similarly to previous studies, the alleles I249 and M280 were in strong linkage disequilibrium and formed an I 249M 280 haplotype. However, there was no relationship between CX3CR1 genotypes or corresponding haplotypes and the prevalence of CAD or MI. Adjusted for classical risk factors (age, sex, hypertension, dyslipidemia, diabetes mellitus and smoking), the odds ratio (OR) of V249I for CAD was 0.95 (95% confidence interval (CI) = 0.78–1.15, p = 0.61). The OR of T280M for CAD was 0.83 (95% CI = 0.66–1.04, p = 0.11). Furthermore, CX3CR1 variants were not associated with C-reactive protein levels, age at onset of CAD, severity of CAD and MI. In conclusion, present data of LURIC do not support the hypothesis that common variants of the CX3CR1 gene are associated with the presence of CAD or MI.