Quality of life in children and adolescents 1-year after cure of Cushing syndrome: a prospective study

• Published in: Clinical endocrinology (Oxford) 2009-09, Vol.71 (3), p.326-333
• Main Authors: Keil, Margaret F., Merke, Deborah P., Gandhi, Roma, Wiggs, Edythe A., Obunse, Kathy, Stratakis, Constantine A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Biological and medical sciences; Child; Child, Preschool; Cushing Syndrome - psychology; Cushing Syndrome - therapy; Endocrinopathies; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Male; Medical sciences; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Prospective Studies; Quality of Life; Surveys and Questionnaires; Vertebrates: endocrinology
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/j.1365-2265.2008.03515.x

Summary Objective  Cushing syndrome (CS) in children is associated with symptoms that may impair health related quality of life (HRQL). There are no prospective reports of HRQL in children with CS. Methods  Prospective study of 40 children (mean age 13 ± 3·2 years) with CS evaluated prior to and 1‐year post‐treatment. The Child Health Questionnaire (CHQ) was used to assess HRQL; Wechsler Intelligence Scale for Children (WASI) was used to assess cognitive function, and patient‐reported symptoms were assessed with a CS symptom checklist. Results  Active CS was associated with low physical and psychosocial summary scores compared to US population data (P