Geniposide from Gardenia jasminoides Attenuates Neuronal Cell Death in Oxygen and Glucose Deprivation-Exposed Rat Hippocampal Slice Culture

Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experim...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2006, Vol.29(1), pp.174-176
Main Authors: Lee, Pyeongjae, Lee, Jongseok, Choi, Sang Yoon, Lee, Sang Eun, Lee, Sanghyun, Son, Dongwook
Format: Article
Language:English
Subjects:
Animals
Cell Death - drug effects
Gardenia - chemistry
Gardenia jasminoides
geniposide
Glucose - deficiency
hippocampal slice culture
Hippocampus - cytology
Hippocampus - drug effects
Hypoxia - pathology
Iridoids - isolation & purification
Iridoids - pharmacology
Neurons - drug effects
OGD
Organ Culture Techniques
Pyramidal Cells - drug effects
Pyrans - isolation & purification
Pyrans - pharmacology
Rats
Rats, Sprague-Dawley
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Summary:Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experimental results, geniposide may be a therapeutic agent for ischemia in patients.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.29.174