Protein Dysregulation in Mouse Hippocampus Polytransgenic for Chromosome 21 Structures in the Down Syndrome Critical Region

Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of th...

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Bibliographic Details
Published in:Journal of proteome research 2006-01, Vol.5 (1), p.44-53
Main Authors: Shin, Joo-Ho, Gulesserian, Talin, Verger, Emmanuelle, Delabar, Jean-Maurice, Lubec, Gert
Format: Article
Language:English
Subjects:
Animals
Chromosomes, Human, Pair 21 - genetics
Down Syndrome - genetics
Down Syndrome - metabolism
Gene Expression Regulation
Hippocampus - chemistry
Hippocampus - metabolism
Humans
Mice
Mice, Transgenic
Protein Biosynthesis - genetics
Proteins - analysis
Proteins - genetics
Proteins - metabolism
Proteome - analysis
Proteome - genetics
Proteome - metabolism
Proteomics
RNA, Messenger - analysis
RNA, Messenger - metabolism
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Summary:Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear- conditioned memory defects and were observed to be dysregulated in human fetal DS. Keywords: polytransgenic mice • chromosome 21 • Down Syndrome critical region • two-dimensional gel electrophoresis • hippocampus
ISSN:1535-3893
1535-3907
DOI:10.1021/pr050235f