Mechanisms of Mechanotransduction

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggest...

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Bibliographic Details
Published in:Developmental cell 2006, Vol.10 (1), p.11-20
Main Authors: Orr, A. Wayne, Helmke, Brian P., Blackman, Brett R., Schwartz, Martin A.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Animals
Biological and medical sciences
Cell Cycle - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Fundamental and applied biological sciences. Psychology
Humans
Hypertension - pathology
Hypertension - physiopathology
Lung - physiology
Mechanotransduction, Cellular - physiology
Models, Biological
Molecular and cellular biology
Muscle, Smooth, Vascular - physiopathology
Myocardium
Neoplasms - physiopathology
Physical Stimulation
Protein Structure, Tertiary - physiology
Signal Transduction - physiology
Stress, Mechanical
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Summary:Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2005.12.006