Hemodynamic effects of bupropion in anesthetized dogs

Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/k...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2006-01, Vol.530 (1), p.124-127
Main Authors: Paganelli, Maria Ondina, Tanus-Santos, José Eduardo, Sabha, Maricene, do Prado, Joaquim Francisco, Chaud, Marco Vinicíus, Martins, Luís Cláudio, Moreno, Heitor
Format: Article
Language:English
Subjects:
Anesthesia, Intravenous
Animals
Antidepressive Agents, Second-Generation - pharmacology
Biological and medical sciences
Blood Pressure - drug effects
Bupropion - pharmacology
Dogs
Dose-Response Relationship, Drug
Female
Male
Medical sciences
Nicotine
Pentobarbital - administration & dosage
Pentobarbital - pharmacology
Pharmacology. Drug treatments
Pneumology
Pulmonary Circulation - drug effects
Pulmonary hypertension
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Smoking cessation
Time Factors
Tobacco, tobacco smoking
Toxicology
Vascular Resistance - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bupropion is a non-nicotinic drug used in smoking cessation therapy. However, its acute effects remain unclear. In this study, we investigated the effects of bupropion on hemodynamic parameters in pentobarbital-anesthetized mongrel dogs. Bupropion administered either in bolus injections (3 or 6 mg/kg, i.v.) or in cumulative doses of 0.01, 0.1, 1, 3 and 10 mg/kg showed, in both studies, a significant increase of mean pulmonary arterial pressure and pulmonary vascular resistance index. These results show that bupropion can elevate the pulmonary pressure. Further investigations should be done to test this effect in smokers with chronic obstructive pulmonary disease.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2005.11.019