Post-translational modifications of naturally processed MHC-binding epitopes

A variety of different post-translational modifications of peptides displayed by class I and II MHC molecules have now been described. Some modifications promote the binding of peptides to MHC molecules, and might also influence the ability of the peptide to be produced by antigen processing pathway...

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Bibliographic Details
Published in:Current Opinion in Immunology 2006-02, Vol.18 (1), p.92-97
Main Authors: Engelhard, Victor H, Altrich-Vanlith, Michelle, Ostankovitch, Marina, Zarling, Angela L
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Epitopes - metabolism
Humans
Major Histocompatibility Complex - immunology
Peptides - metabolism
Protein Processing, Post-Translational
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Summary:A variety of different post-translational modifications of peptides displayed by class I and II MHC molecules have now been described. Some modifications promote the binding of peptides to MHC molecules, and might also influence the ability of the peptide to be produced by antigen processing pathways. In some instances, the antigen processing components themselves are actually responsible for generating post-translational modifications. Finally, evidence is accumulating that modifications can be altered as a consequence of inflammation, transformation, apoptosis and aging. This leads to altered repertories of MHC-associated peptides, which may be important in immune responses associated with autoimmune diseases, infection and cancer.
ISSN:0952-7915
1879-0372
1365-2567
DOI:10.1016/j.coi.2005.11.015