Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease

Elevated plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide production, are reported to be associated with coronary artery disease (CAD). We measured plasma levels of ADMA and related compounds, nitrate + nitrite (NO x ), total homocysteine (tHCY) and assess...

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Bibliographic Details
Published in:Atherosclerosis 2006-02, Vol.184 (2), p.383-388
Main Authors: Wang, Jun, Sim, Ah Siew, Wang, Xing Li, Salonikas, Chris, Naidoo, Daya, Wilcken, David E.L.
Format: Article
Language:English
Subjects:
Adult
Aged
Arginine - analogs & derivatives
Arginine - blood
Asymmetric dimethylarginine
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Cardiology. Vascular system
Chromatography, High Pressure Liquid
Coronary Angiography
Coronary artery disease
Coronary Disease - blood
Coronary Disease - diagnostic imaging
Coronary Disease - physiopathology
Coronary heart disease
Disease Progression
Female
Follow-Up Studies
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Heart
Homocysteine
Homocysteine - blood
Humans
Male
Medical sciences
Middle Aged
Nitric Oxide Synthase - antagonists & inhibitors
Prognosis
Renal function
Retrospective Studies
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Smoking
Smoking - adverse effects
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Summary:Elevated plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide production, are reported to be associated with coronary artery disease (CAD). We measured plasma levels of ADMA and related compounds, nitrate + nitrite (NO x ), total homocysteine (tHCY) and assessed renal function and lipid profiles in 145 patients—75 with triple vessel coronary disease and 70 with no detectable coronary disease. Levels of ADMA, l-arginine, l-arginine/ADMA and plasma NO x were not different in the two groups but smokers with triple vessel disease had higher ADMA and lower NO x levels than the non-smokers, relationships also present for all smokers and non-smokers in the two groups combined. In all 145 patients ADMA, symmetric dimethylarginine (SDMA) and tHCY levels were significantly higher in patients with glomerular filtration rate (GFR)
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2005.05.002