X-ray Reflectivity Study on the Structure and Phase Stability of Mixed Phospholipid Multilayers

Vertically oriented multilayers composed of two saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphoserine (DPPS), were deposited on silicon. X-ray reflectivity was used to investigate the structures of the variously mixed phospholipid...

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Bibliographic Details
Published in:Langmuir 2009-04, Vol.25 (7), p.4198-4202
Main Authors: Jing, H. Y, Hong, D. H, Kwak, B. D, Choi, D. J, Shin, K, Yu, C.-J, Kim, J. W, Noh, D. Y, Seo, Y. S
Format: Article
Language:English
Subjects:
Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials
Chemistry
Colloidal state and disperse state
Electrons
Exact sciences and technology
General and physical chemistry
Phospholipids - chemistry
Surface physical chemistry
X-Ray Diffraction
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Summary:Vertically oriented multilayers composed of two saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphoserine (DPPS), were deposited on silicon. X-ray reflectivity was used to investigate the structures of the variously mixed phospholipid multilayers as a function of composition. Then, the phase stability was investigated at various annealing temperatures under humid conditions. The results indicated that the lipid spacing of the mixed phospholipid multilayers varied systematically as a function of the DPPC/DPPS ratio and that no macroscopic phase separation occurred during the annealing process under both dry and humid conditions.
ISSN:0743-7463
1520-5827
DOI:10.1021/la802868r