Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI: comparison between healthy adults and patients with pulmonary hypertension

To assess the stability and reproducibility of different breath-hold levels in healthy volunteers and patients using dynamic MRI (dMRI). In ten healthy volunteers and ten patients with pulmonary hypertension (PH) and normal lung function craniocaudal intrathoracic distances (CCD) were measured durin...

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Bibliographic Details
Published in:European radiology 2006-01, Vol.16 (1), p.173-179
Main Authors: Plathow, Christian, Ley, Sebastian, Zaporozhan, Julia, Schöbinger, Max, Gruenig, Ekkehard, Puderbach, Michael, Eichinger, Monika, Meinzer, Hans-Peter, Zuna, Ivan, Kauczor, Hans-Ulrich
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Exhalation - physiology
Expiration
Female
Humans
Hypertension
Hypertension, Pulmonary - physiopathology
Image Processing, Computer-Assisted - methods
Inhalation - physiology
Inspiration
Lung - anatomy & histology
Lung - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Observer Variation
Pulmonary hypertension
Reference Values
Reproducibility
Reproducibility of Results
Respiratory function
Stability
Statistical analysis
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Summary:To assess the stability and reproducibility of different breath-hold levels in healthy volunteers and patients using dynamic MRI (dMRI). In ten healthy volunteers and ten patients with pulmonary hypertension (PH) and normal lung function craniocaudal intrathoracic distances (CCD) were measured during inspiratory and expiratory breath-hold (15 s) (in healthy volunteers additionally at a self-chosen mid-inspiratory breath-hold) using dMRI (trueFISP, three images/s). To evaluate stability and intraobserver reproducibility of the different breath-hold levels, CCDs, time-distance curves, confidence intervals (CIs), Mann-Witney U test and regression equations were calculated. In healthy volunteers there was a substantial decrease of the CCD during the inspiratory breath-hold in contrast to the expiratory breath-hold. The CI at inspiration was 2.84+/-1.28 in the right and 2.1+/-0.68 in the left hemithorax. At expiration the CI was 2.54+/-1.18 and 2.8+/-1.48. Patients were significantly less able to hold their breath at inspiration than controls (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-005-2795-9