Treatment advances for medically inoperable non-small-cell lung cancer: emphasis on prospective trials

Summary Advances in technology have changed the treatment of patients with early stage non-small-cell lung cancer who are not healthy enough for standard surgical resection. Previously, patients with severe underlying cardiopulmonary dysfunction were often dissuaded from pursuing definitive therapy,...

Full description

Saved in:
Bibliographic Details
Published in:The lancet oncology 2009-09, Vol.10 (9), p.885-894
Main Authors: Powell, John W, MD, Dexter, Elisabeth, MD, Scalzetti, Ernest M, MD, Bogart, Jeffrey A, Prof
Format: Article
Language:English
Subjects:
Brachytherapy - methods
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - radiotherapy
Carcinoma, Non-Small-Cell Lung - surgery
Catheter Ablation - methods
Dose Fractionation
Hematology, Oncology and Palliative Medicine
Humans
Lung cancer
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Lung Neoplasms - surgery
Radiosurgery - methods
Radiotherapy, Conformal - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Advances in technology have changed the treatment of patients with early stage non-small-cell lung cancer who are not healthy enough for standard surgical resection. Previously, patients with severe underlying cardiopulmonary dysfunction were often dissuaded from pursuing definitive therapy, even though most patients died from their lung cancer and not as a result of comorbid medical illness. Recent advances in the technology to treat early stage disease have led to new-found enthusiasm for treating and studying high-risk patients. This Review focuses on the management of these patients, including use of conformal radiotherapy, stereotactic body radiation therapy, sublobar resection, intraoperative brachytherapy, and radiofrequency ablation. Ongoing challenges are presented and prospective data are emphasised.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(09)70103-2