Autoantibodies in Argentine Women with Recurrent Pregnancy Loss

Problem To determine the presence or absence of subclinical autoimmunity in Caucasian Argentine healthy women with first trimester recurrent pregnancy loss (RPL), the sera of 118 healthy women with a history of three or more consecutive abortions and 125 fertile control women without abortions and t...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2006-03, Vol.55 (3), p.201-207
Main Authors: Bustos, Daniel, Moret, Ana, Tambutti, Monica, Gogorza, Sebastian, Testa, Roberto, Ascione, Amanda, Prigoshin, Norma
Format: Article
Language:English
Subjects:
Abortion, Habitual - blood
Abortion, Habitual - epidemiology
Abortion, Habitual - immunology
Adult
Argentina - epidemiology
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
autoimmunity
Enzyme-Linked Immunosorbent Assay - methods
Female
Humans
Middle Aged
Pregnancy
recurrent pregnancy loss
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Summary:Problem To determine the presence or absence of subclinical autoimmunity in Caucasian Argentine healthy women with first trimester recurrent pregnancy loss (RPL), the sera of 118 healthy women with a history of three or more consecutive abortions and 125 fertile control women without abortions and two children were analyzed for the presence of autoantibodies: immunoglobulin (Ig)G and IgM anticardiolipin, antinuclear (ANA), antismooth muscle (ASMA), antimitocondrial (AMA), antiliver‐kidney‐microsomal fraction (LKM), antigastric parietal cells (GPC), antineutrophil cytoplasmatic (ANCA) and antibodies antigliadin type IgA and IgG and IgA antitransglutaminase related with celiac disease (CD). Method of study ANA, ASMA, AMA, anti‐LKM, antibodies to GPC and ANCA were determined by indirect immunofluorescence (IFI) and anticardiolipin, antigliadina and antitransglutaminase antibodies were measured by enzyme‐linked immunosorbent assays (ELISA). Results There was no significant difference between controls and patients with ANA, ASMA, AMA, LKM, ANCA and GPC. The prevalence of anticardiolipin antibodies in RPL was significantly higher than controls (P 
ISSN:1046-7408
1600-0897
DOI:10.1111/j.1600-0897.2005.00349.x