Differentiation and Apoptosis in UVA-Irradiated Cells Treated with Furocoumarin Derivatives

In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, includin...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-08, Vol.1171 (1), p.334-344
Main Authors: Viola, Giampietro, Salvador, Alessia, Vedaldi, Daniela, Dall'Acqua, Francesco, Bianchi, Nicoletta, Zuccato, Cristina, Borgatti, Monica, Lampronti, Ilaria, Gambari, Roberto
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - radiation effects
Biological effects
Cancer
cell cycle
Cell Cycle - drug effects
Cell Differentiation - drug effects
Cell Differentiation - radiation effects
Derivatives
Differentiation
Diseases
Disorders
erythroid differentiation
erythroid precursors
Ficusin - chemistry
Ficusin - pharmacology
Furocoumarins - chemistry
Furocoumarins - pharmacology
Humans
K562 cells
Molecular Structure
psoralens
PUVA Therapy - methods
Therapy
Ultraviolet Rays
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Summary:In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several diseases, including psoriasis, mycosis fungoides and cancer. Also, preclinical data demonstrate a possible use of these molecules for the treatment of β‐thalassemia and other hematological disorders.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1111/j.1749-6632.2009.04894.x