Hemorheological follow-up after splenectomy and spleen autotransplantation in mice

We previously reported on a spleen autotransplantation model in mice, with spleen function studies at 6 weeks. The present study was undertaken to investigate long‐term hemorheological functions. A/J and BALB/c inbred mice were divided into four groups: control, sham surgery (SH), splenectomy (SE),...

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Published in:Microsurgery 2006, Vol.26 (1), p.38-42
Main Authors: Miko, Iren, Nemeth, Norbert, Sipka Jr, Sandor, Brath, Endre, Peto, Katalin, Gulyas, Adrienn<, Furka, Istvan, Zhong, Robert
Format: Article
Language:English
Subjects:
Animals
Blood Cell Count
Erythrocyte Deformability
Hematocrit
Hemoglobins - metabolism
Hemorheology
Mice
Mice, Inbred Strains
Spleen - transplantation
Splenectomy
Time Factors
Transplantation, Autologous
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Summary:We previously reported on a spleen autotransplantation model in mice, with spleen function studies at 6 weeks. The present study was undertaken to investigate long‐term hemorheological functions. A/J and BALB/c inbred mice were divided into four groups: control, sham surgery (SH), splenectomy (SE), and spleen autotransplantation (AU). Hematological and hemorheological parameters were determined. Leukocyte counts in the SE and AU groups were significantly higher than in controls, while hematocrit levels were markedly lower. Mean erythrocyte volume did not change significantly. Platelet counts in the AU group were significantly lower, and red blood cell deformability was significantly worse in the SE group. The AU group also had increased cell transit time, but it was less than that in the SE group. The SE group showed the highest fibrinogen levels. We conclude that there are some consistent differences in hematological parameters between splenectomy and spleen autotransplantation. These data suggest that spleen autotransplantation may partially restore hemorheological functions following splenectomy. © 2006 Wiley‐Liss, Inc. Microsurgery 26: 38–42, 2006.
ISSN:0738-1085
1098-2752
DOI:10.1002/micr.20208