Acute and sustained effects of lucinactant versus poractant-α on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome

Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compar...

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Published in:Pediatrics (Evanston) 2006-02, Vol.117 (2), p.295-303
Main Authors: GASTIASORO-CUESTA, Elena, ALVAREZ-DIAZ, Francisco J, REY-SANTANO, Carmen, ARNAIZ-RENEDO, Arantxa, LOUREIRO-GONZALEZ, Begona, VALLS-I-SOLER, Adolf
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Biological Products - therapeutic use
Blood Gas Analysis
Blood Pressure
Causes of
Drug Combinations
Fatty Alcohols - therapeutic use
General aspects
Gestational Age
Heart Rate
Humans
Infant, Newborn
Medical sciences
Phosphatidylglycerols - therapeutic use
Phospholipids - therapeutic use
Pneumology
Proteins - therapeutic use
Pulmonary Gas Exchange
Pulmonary surfactant
Pulmonary surfactants
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - drug therapy
Respiratory Distress Syndrome, Newborn - physiopathology
Respiratory system : syndromes and miscellaneous diseases
Risk factors
Sheep
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Summary:Animal-derived, protein-containing surfactants seem to be superior to protein-free surfactants. Lucinactant, a synthetic surfactant containing a surfactant protein-B peptide analog, has been shown to be effective in animal models and phase II clinical trials. To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model. The objective was to compare the acute and sustained effects of lucinactant among premature lambs with respiratory distress syndrome (RDS) with the effects of a natural porcine surfactant (poractant-alpha). After 5 minutes of mechanical ventilation twin premature lambs were assigned randomly to the lucinactant group (30 mg/mL, 5.8 mL/kg) or the poractant-alpha group (80 mg/mL, 2.2 mL/kg). Heart rate, systemic arterial pressure, arterial pH, blood gas values, and lung mechanics were recorded for 12 hours. Baseline fetal pH values were similar for the 2 groups (pH 7.27). After 5 minutes of mechanical ventilation, severe RDS developed (pH: 80 mm Hg; Pao2:
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2005-0378